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Updated: Sep 16, 2025

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在KRAS突变癌症中,EGFR阻断对泛RAS抑制剂产生敏感性

Junling Han1,2, Bo Yu3,2, Jianan Jing4,3,2

  • 1College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.

Cellular oncology (Dordrecht, Netherlands)
|July 10, 2025
PubMed
概括

结合EGFR和泛RAS抑制剂显示出对KRAS突变癌症的前景. 这种策略通过向抗药机制来增强抗瘤活性,为难以治疗的瘤患者提供新的治疗选择.

关键词:
有KRAS突变的癌症通过CRISPR/Cas9 sgRNA查进行查.组合疗法是一种组合疗法.作为EGFR抑制剂的使用.全RAS 抑制剂 泛RAS 抑制剂在RTK-RAS-RAF-MEK-ERK路径中.

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