内膜前额叶皮层向自主大脑干的投射:量化输入的胆固醇和上腺/上腺核
Ema Lukinic1, Tyler Wallace1, Carlie McCartney1
1Department of Biomedical Sciences, Colorado State University, 1617 Campus Delivery, Fort Collins, CO, 80523, USA.
鼠类的内膜皮层 (IL) 投射到控制自主功能的大脑干区域. 这项研究绘制了IL连接到神经元的地图,这些神经元调节了副交感,同情和恒常反应.
科学领域:
- 神经科学是一个神经科学.
- 自主神经系统的自主神经系统
- 前额叶皮层功能 前额叶皮层功能
背景情况:
- 腹中前额叶皮质,包括下边缘皮质 (IL),影响情绪和生理状态.
- IL 整合了应激反应,但它对大脑干自主核的投射尚未得到充分理解.
研究的目的:
- 为了研究IL的组织,在雄性大鼠中向自主大脑干核的谷氨基基射.
- 测试假设IL投射差异地准了副交感和上腺体/上腺体核.
主要方法:
- 利用病毒介导的基因转移来表达IL质神经元中的黄色光蛋白 (YFP).
- 通过成像对胆固醇和上腺体/上腺体核进行量化YFP阳性预测.
主要成果:
- IL投射激活了迷宫的背部运动核 (副交感) 并准了许多类甲基胺细胞群.
- 在单独通道 (C2,A2),腹侧髓 (C1,A1) 和部 (A6) 的核中观察到高IL输入密度.
- 此外,IL还被投射到局部GABAergic神经元,调节自主前细胞核.
结论:
- IL金字塔神经元投射到腹侧髓中的前性副交感神经元和前交感神经元.
- 这些发现将IL电路映射到关键的平稳调节器中,包括孤独通道的核和coeruleus位置.
- 提供了一个电路层面的框架,用于理解神经控制恒常和自主平衡的神经控制.
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