儿科脑膜瘤和发作:一个范围审查
Emma Ye1, Ashwin Gupta1, Alexander T Lyons1
1Vanderbilt University School of Medicine, Nashville, TN, USA.
概括
儿科脑膜瘤在约36%的病例中与有关. 手术切除可以改善的自由度,但需要对抗药物和分子链接进行进一步的研究.
科学领域:
- 神经瘤学神经瘤学
- 儿科神经学 儿科神经学
- 神经外科 神经外科
背景情况:
- 儿科脑膜瘤是罕见的瘤,具有明显的临床特征.
- 发作是儿科脑膜瘤的一个显著的临床表现.
研究的目的:
- 审查儿科脑膜瘤和发作之间的关联.
- 分析发作表现,手术后的结果以及切除程度和瘤等级的影响.
- 确定关于抗发作药物和分子因素的研究缺口.
主要方法:
- 对儿科脑膜瘤病例进行系统的文献搜索.
- 对发作频率,术后发作结果和使用抗药物 (ASM) 的分析.
- 使用比例z测试 (p < 0.05) 的统计分析.
主要成果:
- 在824例儿科脑膜瘤病例中,35.6%出现了发作.
- 在分级瘤中,70.8%是I级,16.8%是II级,12.4%是III级.
- 在65.8%的患者中,术后发作自由得到了实现;亚总切除与较差的发作结果相关 (28.6%的发作自由).
结论:
- 发作在儿科脑膜瘤中很常见,发生在诊断时或术后.
- 手术切除是标准的护理,切除范围更大与更好的发作结果相关.
- 需要进一步研究切割后ASM的作用以及儿科脑膜瘤中的分子基础.
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