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Updated: Sep 16, 2025

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一个非正规的cGAS-STING通路驱动细胞和生物的衰老

Rafael Cancado de Faria1, Lilian N D Silva1, Barbara Teodoro-Castro1

  • 1Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104.

Proceedings of the National Academy of Sciences of the United States of America
|July 10, 2025
PubMed
概括

衰老细胞表现出激活常规循环-GMP-AMP合成酶 (cGAS) -干扰素基因刺激器 (STING) 途径的能力降低. 相反,一个非正规的途径被触发,驱动衰老的表型和炎症.

关键词:
老化的老化 衰老的老化cGAS 是一个气体.细胞质DNA是细胞质DNA.与衰老相关的分泌表现型干扰素基因的刺激剂.

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