多元化细分失焦优化镜头,有和没有近视预防的氨酸:一项随机临床试验
Yuchang Lu1,2,3,4, Xue Yang5, Jingwei Zhou1,3,4
1Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
JAMA ophthalmology
|July 10, 2025
概括
多元化细分失焦优化 (DSDO) 眼镜镜头有效地预防儿童近视发作. 与标准眼镜相比,DSDO眼镜,有或没有热素,显著降低了近视发病率和进展.
科学领域:
- 眼科医生 眼科 眼科
- 儿科光学测量 儿科光学测量
- 控制近视 控制近视
背景情况:
- 近视的全球流行率不断上升,需要有效的早期近视预防策略.
- 目前的近视控制方法包括药物干预和专门的光学设计.
研究的目的:
- 评估多元化细分失焦优化 (DSDO) 眼镜镜片在预防近视方面的有效性.
- 评估DSDO镜片和低剂量氨酸 (0.01%) 对近视预防的联合作用.
主要方法:
- 一年,随机的,安慰剂控制的,双面罩的临床试验,涉及450名5-12岁的儿童,具有低折射误差.
- 参与者被分为三组:使用安慰剂滴滴的DSDO眼镜,使用0.01%氨酸滴滴的DSDO眼镜或使用安慰剂滴滴的单视眼镜.
- 测量的主要结果是近视的累积发病率和12个月内快速近视转移的参与者的百分比.
主要成果:
- 与对照组 (15.3%) 相比,DSDO (5.8%) 和DSDOA (4.8%) 组中近视的累积发病率明显较低.
- 快速近视转移的参与者的百分比在DSDO (15.7%) 和DSDOA (9.6%) 组与对照组 (42.7%) 相比大幅降低.
- 在DSDO和DSDOA治疗组之间没有发现有效性的显著差异.
结论:
- 每天使用DSDO眼镜镜片是延迟儿童近视发作的有效策略.
- DSDO眼镜是儿童近视预防的可行的替代方法,可能不需要使用阿特罗平.
- 建议进行进一步的长期研究和独立复制,以证实这些发现.
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