贵族的悖论:金色的TEM网格如何破坏细胞完整性,而则保持稳定性
Yongdeok Ahn1, Juhyeong Cho1, Siwoo Jin1
1Department of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea. livewire@dgist.ac.kr.
Chemical communications (Cambridge, England)
|July 10, 2025
概括
黄金和材料对细胞结构的影响不同. 黄金通过产生反应性氧物种而造成损伤,而防止氧化应激,保持细胞完整性和细胞器,如内细胞网.
科学领域:
- 生物材料科学 生物材料科学
- 细胞生物学 细胞生物学
- 毒理学 毒理学 毒理学
背景情况:
- 黄金 (Au) 通常被认为是惰性的,但其氧化还原循环产生反应性氧物种 (ROS).
- (Ni) 具有氧化稳定性,这限制了电荷转移和随后的氧化应激.
- 了解基于材料的细胞相互作用对于开发生物相容复合系统至关重要.
研究的目的:
- 研究基于黄金 (Au) 和 (Ni) 的基板对细胞完整性的差异影响.
- 为了比较Au和Ni诱导氧化应激和损害器官功能的能力.
- 根据观察到的细胞反应,重新评估复合系统中的材料生物相容性.
主要方法:
- 在细胞模型中对基于Au和基于Ni的基质进行比较分析.
- 对反应性氧物种 (ROS) 生产的评估.
- 评价有机体完整性,特别是内质网膜 (ER) 管道.
主要成果:
- 基于Au的基质诱导了ROS的产生,导致细胞损伤和器官破坏.
- 基于Ni的基质表现出氧化稳定性,防止ROS生成并保持细胞完整性.
- 在Ni基基板上,内质网膜 (ER) 管道保持完整,与暴露在Au基材料上的管道不同.
结论:
- 黄金的氧化还原活性,而不是它的惰性,驱动细胞妥协.
- 的氧化稳定性为生物材料应用提供了更安全的替代方案,保护细胞结构.
- 在复合材料系统中的材料选择必须考虑氧化还原特性,以获得最佳的生物相容性,并避免意外的细胞损伤.
相关概念视频
02:37DNA Damage can Stall the Cell Cycle
9.3K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.3K
01:14Diamagnetic Shielding of Nuclei: Local Diamagnetic Current
956
An applied magnetic field causes the electrons present in the molecule to circulate, setting up a local diamagnetic current within the molecule. The local diamagnetic current arising from circulating sigma-bonding electrons induces a magnetic field, Blocal that opposes the applied magnetic field, B0. The effective magnetic field experienced by these nuclei is given by the difference between the applied and local magnetic fields in a phenomenon called local diamagnetic shielding. Essentially,...
956
01:16Necrosis
4.8K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.8K
02:47Voltaic/Galvanic Cells
58.4K
Spontaneous Chemical Reactions
Spontaneous redox reactions occur abundantly in nature. The chemical reaction occurring in a disposable AA battery powering our remote controls is one such example of a spontaneous redox reaction. Another example is the immersion of coiled copper wire into an aqueous silver nitrate solution. The reaction shows a gradual, visually impressive color change from colorless to bright blue and the formation of a grey precipitate on the copper wire. In this experiment,...
Spontaneous redox reactions occur abundantly in nature. The chemical reaction occurring in a disposable AA battery powering our remote controls is one such example of a spontaneous redox reaction. Another example is the immersion of coiled copper wire into an aqueous silver nitrate solution. The reaction shows a gradual, visually impressive color change from colorless to bright blue and the formation of a grey precipitate on the copper wire. In this experiment,...
58.4K