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新型硫衍生物的设计,合成和杀虫活动

Feng Hao¹, Wenxuan Wu¹, Kaida Li¹

¹Key Laboratory of Medicinal Chemistry for Natural Resource, Yunnan Characteristic Plant Extraction Laboratory, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.

Journal of agricultural and food chemistry

|July 10, 2025

概括

新型硫化合物对关键的虫虫害有强大的杀虫活性,为传统农药提供了更安全的替代品. 化合物W-27和W-29显示出卓越的疗效,为新的农业化学开发铺平了道路.

科学领域:

农业化学农业化学
有机化学有机化学
昆虫学昆虫学是一门学科.

背景情况:

全球人口的增加增加了粮食需求,加剧了虫虫害的挑战.
传统的化学杀虫剂面临着害虫耐药性和环境破坏等问题,需要新的解决方案.
硫化合物有可能提高杀虫剂的有效性,同时减少对环境的影响.

研究的目的:

设计和合成新的硫化合物,以提高杀虫效果.
针对关键的类虫虫害,包括 *Spodoptera litura*, *Spodoptera frugiperda* 和 *Spodoptera exigua*.
探索可持续农业害虫防治的新架构.

主要方法:

在化合物设计中采用了跳策略和生物电子原理.
评估了杀性活性,并分析了结构-活性关系 (SAR).
进行了分子对接,3D-QSAR建模和对非目标生物的毒性测试.

主要成果:

化合物W-27和W-29表现出显著的杀性活性,超过了积极对照fluralaner.
对W-27和W-29的LC50值分别为0.1205毫克/升和0.1262毫克/升.
SAR,对接和3D-QSAR研究阐明了活性机制,毒性测试证实了环境安全.

结论:

新型硫化合物显示出高杀虫力和有利的环境特征.
化合物W-27和W-29代表了开发下一代农业化学品的有希望的线索.
这项研究为有效和可持续的害虫管理策略提供了新的支架.

关键词:

杀虫活动杀虫活动分子对接的分子对接.新型杀虫剂是一种新型杀虫剂.硫化合物是一种硫化合物.

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