抗生素反抗的沙门氏菌利用抗生素后的微生物群破坏来实现依赖于毒性的传播
Joshua P M Newson1, Sarah C McHugh1, Yves Steiger1
1Institute of Microbiology, ETH Zurich, Zurich, Switzerland.
Cell reports
|July 10, 2025
概括
抗生素治疗可能无法清除沙门氏菌 Typhimurium 感染,允许细菌从隐藏的水库重新生长并传播给新的宿主. 幼稚动物的完整的肠道微生物群可以阻止这种传播.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 宿主-病原体相互作用
背景情况:
- 抗生素复发储存是细菌感染清除失败和复发的关键因素.
- 沙门氏菌 Typhimurium 在抗生素暴露后可以在宿主组织中持续存在,后来恢复复制并重新播种肠道.
- 了解沙门氏菌毒性因素和抗生素治疗如何影响感染复发和传播至关重要.
研究的目的:
- 调查抗生素治疗对沙门氏菌Typhimurium在老鼠长期系统感染期间的影响.
- 阐明沙门氏菌毒性因子在抗生素后再生和传播中的作用.
- 探索宿主微生物群对传播动态的影响.
主要方法:
- 在129/SvEv小鼠中,Salmonella Typhimurium的长期系统感染模型.
- 服用塞夫特里亚克松抗生素治疗.
- 在体内和肠道膜中监测可板状病原体负载.
- 对具有不同微生物群状况的天真友传播的评估.
主要成果:
- 可接受的沙门氏菌负载在治疗中减少,但在治疗后增加,这是由细胞内毒性因素促进的再生.
- 在肠道中观察到大量的沙门氏菌繁殖,导致克隆传播和类动物的侵入性感染.
- 在与具有完整微生物群的幼稚小鼠进行的共同住房实验中,有效地阻止了传播,证明了殖民抵抗力.
结论:
- 抗生素治疗可以在宿主组织中建立沙门氏菌Typhimurium的抗生素反抗容器.
- 病原体-宿主-微生物群的动态极大地影响了沙门氏菌感染的持续性,再生和传播.
- 完整的宿主微生物群为抗生素耐药性细菌感染的传播提供了强大的防御.
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