母亲产前和产后压力和婴儿感染
S Hyvönen1,2, T Solasaari2,3, T Pokka4,5
1Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
Acta paediatrica (Oslo, Norway : 1992)
|July 10, 2025
概括
母亲产前压力,特别是与家庭有关的压力,在患有感染的婴儿中更高. 这表明产前压力可能是婴儿早期感染的危险因素,这需要进一步调查减压支持.
科学领域:
- 围产期健康 围产期健康
- 婴儿免疫学 婴儿免疫学
- 压力研究 压力研究
背景情况:
- 怀孕期间母亲的压力是围产期健康日益关注的问题.
- 了解产前压力对婴儿健康结果的影响对于早期干预至关重要.
- HELMi队列为研究婴儿健康和环境因素提供了宝贵的资源.
研究的目的:
- 调查怀孕最后三个月期间母亲的压力与儿童早期感染的发生率之间的联系.
- 为了比较婴儿在生命的前六个月内感染和没有感染的母亲的压力水平.
- 探索母乳皮质醇作为母亲压力的潜在生物标志物及其与婴儿感染的关系.
主要方法:
- 在怀孕后期使用验证的问卷来评估母亲的压力.
- 母乳皮质醇水平在分娩后三个月被测量.
- 婴儿感染事件和症状通过在线日记精心记录.
- 统计分析对潜在的混因素进行了控制,例如出生季节和兄弟姐妹数量.
主要成果:
- 与对照组相比,患有感染的婴儿的母亲报告了与家庭相关的产前压力水平显著更高 (p=0.02).
- 两组之间没有观察到与怀孕或关系因素相关的压力显著差异.
- 母乳皮质醇水平在感染和没有感染的婴儿之间没有差异,这表明在这种情况下它可能不是一个敏感的指标.
结论:
- 产前压力,特别是关于家庭因素的压力,与婴儿早期感染风险增加有关.
- 这些发现强调了母亲心理健康在塑造婴儿免疫反应方面的潜在作用.
- 需要进一步的研究来确定旨在减少产前压力的干预措施是否可以减轻婴儿感染的风险.
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