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通过阻断膜抗原的蛋白质体降解来提高CAR T细胞的效率

Leonie Rieger1, Kilian Irlinger1, Franziska Füchsl2

  • 1Technical University of Munich, TUM University Hospital, München, Germany.

Blood
|July 10, 2025
PubMed
概括

像卡菲尔佐米布这样的蛋白质酶抑制剂可以增强B细胞成熟抗原 (BCMA) 在多发性髓瘤细胞上的表达. 这一策略可能会改善化学抗原受体 (CAR) T 细胞治疗在初始治疗后复发的患者的疗效.

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