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Updated: Sep 16, 2025

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在雄性生殖系中,L-2-基酸盐调节了中间体和异色染色体的构成

Nina Mayorek1, Miriam Schlossberg1, Yousef Mansour1

  • 1The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.

PLoS genetics
|July 10, 2025
PubMed
概括

在丸中由乳酸脱酶C (LDHC) 生产的L-2-基酸盐 (L-2HG) 在男性生殖细胞发育过程中调节中心粒凝聚和异色素组织. 它的耗尽会导致中粒体功能障碍和染色体分离错误.

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