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Updated: Jun 17, 2026

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丸癌抗原表达与小肠神经内分泌瘤中的免疫激活和存活相关

Reed I Ayabe1,2, Y David Seo1,3, Brenda Melendez4

  • 1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

JCO precision oncology
|July 10, 2025
PubMed
概括

在小肠神经内分泌瘤 (SBNET) 中,高癌症丸抗原 (CTA) 表达与更好的生存率和免疫激活相关. 这表明,将表观遗传修饰剂与免疫疗法结合起来,可能会改善SBNET治疗结果.

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...