第三季度母亲低血压与怀孕年龄出生体重较小的孕妇轻度慢性高血压患者之间的关系
Kim Boggess1, Justin Leach, Lorraine Dugoff
1University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Duke University, Durham, North Carolina; the University of Alabama at Birmingham, Birmingham, and South Alabama University, Mobile, Alabama; the University of Pennsylvania, Philadelphia, St. Luke's University Health Network, Bethlehem, Penn State University, University Park, and Magee-Womens Hospital, Pittsburgh, Pennsylvania; the University of Houston and HCA Healthcare, Houston, and the University of Texas, Austin, Texas; the University of Florida, Gainesville, Florida; MetroHealth, Cleveland, The Ohio State University, Columbus, Cincinnati Children's Hospital, Cincinnati, and Premier Health, Dayton, Ohio; Indiana University, Indianapolis, Indiana; the University of Utah, Salt Lake, Utah; Ochsner Health and Tulane University, New Orleans, Louisiana; West Virginia University, Morgantown, West Virginia; Eastern Virginia Medical School, Norfolk, Virginia; the University of Wisconsin, Madison, and the Medical College of Wisconsin, Milwaukee, Wisconsin; Saint Peter's University Hospital and Rutgers University, New Brunswick, New Jersey; the University of Mississippi, Jackson, Mississippi; NYU Langone Health, Garden City, and Cornell University, New York, New York; the University of Colorado, Aurora, Colorado; Emory University, Atlanta, Georgia; the University of California, San Francisco, San Francisco, and Stanford University, Stanford, California; Oregon Health & Science University, Portland, Oregon; the Medical University of South Carolina, Charleston, South Carolina; Vanderbilt University, Nashville, Tennessee; and the National Institutes of Health, Bethesda, Maryland.
对轻度慢性高血压的治疗很少导致低血压 (BP). 第三个三个月的低血压与分娩小于妊娠年龄 (SGA) 的新生儿没有显著联系.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 在怀孕期间高血压.
背景情况:
- 轻度慢性高血压会影响很大一部分怀孕.
- 在怀孕期间管理高血压对于母亲和胎儿的结果至关重要.
- 在CHAP研究中,研究了治疗对怀孕结果的影响.
研究的目的:
- 为了确定为轻度慢性高血压治疗的患者的第三季度低血压 (BP) 是否与分娩小于妊娠年龄 (SGA) 新生儿有关.
- 分析特定血压值与SGA出生体重之间的关系.
主要方法:
- 对CHAP研究数据的二次分析.
- 包括患有轻度慢性高血压的参与者,接受治疗以达到目标血压低于140/90毫米.
- 低血压的定义是平均静脉血压<110 mmHg,静脉血压<70 mmHg,或平均动脉压<80 mmHg.
主要成果:
- 在符合条件的参与者中,低血压 (BP) 不常见 (2.6-2.7%).
- 没有发现低血压与分娩小于妊娠年龄 (SGA) 新生儿之间的显著关联.
- 非线性关系表明,随着平均动脉压的下降,SGA概率较低 (P=.02).
结论:
- 对轻度慢性高血压的药物治疗不经常导致低血压.
- 在这种情况下,低血压似乎不会增加SGA新生儿分娩的风险.
- 目前对轻度慢性高血压的治疗指南在SGA风险方面似乎是安全的.
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