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基于共价有机框架的聚合诱导排放光探针用于检测谷甲

Xingxiang Wang¹, Yaqing Chen¹, Qinqin Nie¹

¹College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

|July 10, 2025

概括

研究人员开发了一种新的光探针,使用功能化COF-1和聚合诱导排放分子来检测敏感的谷氨 (GSH). COF-1&H4tcpe探头提供了更高的性能,具有广泛的线性范围和低的检测极限.

科学领域:

材料科学材料科学材料科学
分析化学分析化学
纳米技术纳米技术

背景情况:

开发用于敏感检测的共价有机框架 (COF) 仍然是一个挑战.
聚合诱导排放 (AIE) 分子具有独特的光特性.
谷氨 (GSH) 是各种生物过程的关键生物标志物.

研究的目的:

合成一种基于COF-1的新型光探针,用于增强GSH的检测.
研究在GSH检测时光增强的机制.
评估开发的GSH量化探针的性能.

主要方法:

合成 (3-氨基) 三氧化 (APTES) 功能化的COF-1纳米片.
通过π-π相互作用将AIE分子 (H4tcpe或H4tcbpe) 吸附到COF-1上.
光光谱检测GSH并分析探测器性能.

主要成果:

一个光探测器 (COF-1&H4tcpe/H4tcbpe) 已成功建造.
通过调节电子云密度和抑制AIE分子旋转,GSH检测导致光增强.
COF-1&H4tcpe探针显示了GSH的宽线性范围 (0.3-400μM) 和低检测极限 (0.10μM).

结论:

开发的基于COF-1的光探针在GSH检测方面表现出色.
这一战略为设计具有选择性的高光COF复合材料提供了一种新方法.
探测器显示了对生物相关分子的敏感和选择性检测的潜力.

关键词:

艾格斯基因 (AIEgens) 是一种共价有机框架是共价有机框架.光发射探测器进行光.葡萄糖氨酸 (Glutathione) 是一种

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