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有针对性的多功能纳米工程碳点,具有增强的协同光热/光动力性能,用于精确的瘤治疗

Hongliang Wang¹, Tian Tian¹, Shuning Xu¹

¹Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China; Shanxi Key Laboratory of Molecular Imaging &, Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, Shanxi 030001, China.

Journal of colloid and interface science

|July 10, 2025

概括

开发了一种新的RGD-Ce/CDs系统,用于增强癌症治疗. 该系统结合了光热和光动力治疗,在体内显示出显著的瘤抑制和近乎完全的切除.

科学领域:

纳米技术纳米技术
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

开发有针对性的癌症疗法对于提高治疗疗效和减少副作用至关重要.
由于其独特的光学特性,碳点 (CD) 具有生物医学应用的潜力.
结合不同的治疗方式可以产生协同作用的抗癌效应.

研究的目的:

合成和表征一种新型的多功能Ce-doped碳点 (CDs) 系统,与素-甘氨酸-酸 (RGD) (RGD-Ce/CDs) 相结合.
评估RGD-Ce/CDs在结合光热疗法 (PTT) 和光动力疗法 (PDT) 中的潜力,以增强瘤向能力.

主要方法:

通过一个简单的策略合成RGD-Ce/CDs.
使用技术来确定粒子大小和分散性的结构特征.
在808nm和1060nm的光热转换效率 (PCE) 的评估.
在近红外 (NIR) 辐射下评估反应性氧物种 (ROS) 的产生.
在瘤携带小鼠的体外和体内研究,以评估治疗疗效和瘤向.

主要成果:

合成了具有优异分散性的统一,超小的RGD-Ce/CD (∼4.75nm).
RGD-Ce/CD表现出强烈的NIR吸收和高的PCE (31.8%在808nm,20.6%在1060nm).
在 NIR 照射下,Ce 兴奋剂促进了 ROS 生成.
RGD-Ce/CDs表现出极好的生物相容性,低细胞毒性和光热稳定性.
在体内研究显示显著的瘤生长抑制和近乎完整的瘤切除与RGD-Ce/CDs在NIR照射下.
通过RGD结合,可以选择性瘤向,最大限度地减少非向效应.

结论:

RGD-Ce/CDs代表了协同 PTT 和 PDT 的一个有前途的多功能平台.
开发的系统表现出增强的瘤向能力和治疗疗效.
这种简单的合成方法为开发用于癌症治疗的先进光疗剂提供了可行的策略.

关键词:

碳点是一些碳点.这是一种RGD.稀土离子是一种稀土离子.目标定位能力目标定位能力瘤的移除是瘤的移除.

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