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Updated: Sep 16, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

在怀孕期间的SARS-CoV-2突破性感染优先引起IgG4反应和增强的胎盘转移

Sheridan B Wagner¹, Monica Rincon², Katelyn E Keen¹

¹Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, United States.

|July 10, 2025

概括

在怀孕期间突破SARS-CoV-2感染增强了母亲的抗体反应,并促进了对新生儿的抗体转移. 建议孕妇继续接种疫苗,以防止严重的COVID-19和新生儿.

科学领域:

免疫学免疫学免疫学
孕产妇和胎儿医学孕产妇和胎儿医学
病毒学病毒学

背景情况:

新出现的SARS-CoV-2变种和免疫力减弱增加了突破性感染.
孕妇和新生儿面临COVID-19的更高风险.

研究的目的:

评估母亲对SARS-CoV-2的IgG反应.
在突破性感染,初级感染或怀孕期间接种疫苗后评估抗体转移到胎儿.

主要方法:

研究了165名孕妇患者,分为三个队列:突破性感染,未接种疫苗的感染和没有感染的疫苗接种.
在母体血液和母乳中长度测量了受体结合域 (RBD) 和核蛋白 (NP) 特定的IgG标位.
在分娩时分析了双对母体,带和新生儿血液.

主要成果:

突破性感染产生了比单独感染或接种疫苗更高的母体RBD特异性IgG.
突破性感染使RBD特异性IgG偏向IgG4;IgG1和IgG3主导了NP特异性反应.
在突破性感染队列中观察到最高的新生儿对母体IgG比率,与强烈的母婴新生儿标位相关性.

结论:

孕期突破性感染延长了幽默免疫力,并增强了对新生儿的胎盘抗体转移.
由于先前接种疫苗而形成的抗体,而不是单独感染,推动了增强的转移.
在怀孕期间更新SARS-CoV-2疫苗接种对于减少疾病严重程度和保护新生儿至关重要.

关键词:

在前面的部分.抗体是对抗体的一种.在 COVID-19 疫情中,免疫球蛋白是一种免疫球蛋白.新生儿新生儿新生儿新生儿

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