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Updated: Sep 16, 2025

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A Murine Model of Group B Streptococcus Vaginal Colonization
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捷克共和国A组链球菌在COVID-19后的激增是由共享毒性因子的emm1和emm12驱动的
Marek Stefan1, Suhanya Prasad2, Ivana Vitkova3
1Department of Infectious Diseases and Travel Medicine, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Journal of infection and public health
|July 10, 2025
概括
捷克共和国2023年A组链球菌 (GAS) 感染急剧增加,主要是由emm1和emm12菌株推动的. 像共享毒性基因和儿童免疫力降低等因素可能导致了这种增加.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 在2023年期间,捷克实验室观察到Streptococcus pyogenes (A组链球菌 - GAS) 培养阳性显著增加.
- 这促使了一项多中心研究,以调查循环菌株的流行病学和特征.
研究的目的:
- 分析2017年至2023年捷克共和国GAS感染的流行病学数据.
- 描述流行GAS菌株的遗传和抗菌敏感性概况.
主要方法:
- 收集了来自11个微生物学部门的2017-2023年GAS阳性培养的数据.
- 从2023年5月开始,对120个GAS分离物进行了全基因组测序和抗菌敏感性测试.
主要成果:
- 与前几年相比,2023年GAS阳性培养的统计学上显著增加,特别是影响儿童.
- 最常见的菌株是emm1 (ST28) 和emm12 (多种ST),显示了跨区域的克隆集群.
- 在emm1和emm12菌株中确定了关键的毒性因素,包括免疫逃避 (sic, sic-drs) 和殖民 (sda1) 基因.
结论:
- 捷克共和国发生了GAS感染的激增,主要是由emm1和emm12菌株引起的.
- 共有的毒性因子,群体免疫力变化和儿童免疫力下降的结合,COVID-19流行后的措施可能解释了传播的增加.
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