基于生活方式的干预措施,针对双相情感障碍中的神经认知 - - 随机对照试验的系统审查
Vicent Balanzá-Martínez1, Alejandro Galdámez-Huertas2, Joan Vicent Sánchez-Ortí3
1Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Avda Blasco Ibáñez, 15, 46010 Valencia, Spain; VALSME (Valencia Estigma i Salut Mental), University of Valencia, Avda Blasco Ibáñez, 15, 46010 Valencia, Spain; Centro de Investigación Biomédica en red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. 28029 Madrid, Spain; INCLIVA Health Research Institute, Menéndez y Pelayo, 4, 46010 Valencia, Spain.
Psychiatry research
|July 10, 2025
概括
基于生活方式的干预措施,特别是特定的营养药物,如胆和肌酸,显示出改善双相情感障碍 (BD) 的认知能力的潜力. 然而,由于研究有限和方法多样化,需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 营养科学 营养科学
背景情况:
- 认知障碍影响着双相情感障碍 (BD) 患者的很大一部分.
- 基于生活方式的干预措施 (LBIs) 显示出改善BD的临床结果的希望.
- 有限的研究存在于LBI的有效性,特别是在BD的认知增强中.
研究的目的:
- 系统地评估随机对照试验 (RCT) 的方法质量,这些试验调查LBI用于BD的认知改善.
- 评估LBI在改善BD患者认知功能的有效性.
主要方法:
- 在主要数据库 (PubMed,Embase,Scopus,Web of Science,PsycINFO,ClinicalTrials.gov) 进行了全面的系统文献搜索,直到2024年2月1日.
- 包括以LBI为认知在BD中的认知重点的RCT,使用验证的神经心理测试.
- 方法质量和偏差风险分别使用PEDro尺度和Cochrane RoB 2工具进行评估;结果以叙事方式综合.
主要成果:
- 分析了7个RCT (n=275),其中6个专注于营养药,一个专注于心身干预.
- 和肌酸显示出潜在的前认知效应,改善声明性记忆,口头学习和口头流利.
- 包含的RCT的整体方法质量很高,偏差风险低.
结论:
- 某些营养药可能对双相情感障碍的认知功能有好处.
- 目前的证据受到研究异质性和小样本大小的限制.
- 未来的研究应该探索整体饮食,体育活动和多式联动的LBI,以提高BD的认知能力.
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