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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
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The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
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The respiratory system is a complex biological apparatus that facilitates the exchange of gases, specifically oxygen and carbon dioxide, between our bodies and the environment. This system plays a vital role in the physiological process of respiration, an essential function for sustaining life.
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The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
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Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
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Updated: Sep 16, 2025

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
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上空气道与下空气道:微生物塑造了当地环境.

Shifen Xu1, Zhang Wang2

  • 1Biomedical Research Center, Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.

Cell host & microbe
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PubMed
概括

呼吸道微生物群影响新陈代谢,在上空气道和下空气道中发现了不同的微生物通路和代谢物. 像Prevotella melaninogenica这样的口腔细菌在下呼吸道中产生关键代谢物,如 inosine 和 glutamate.

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科学领域:

  • 微生物学 微生物学
  • 代谢学 代谢学 代谢学
  • 人体生理学 人体生理学

背景情况:

  • 人的呼吸道是一个复杂的微生物群.
  • 呼吸道微生物的代谢活动尚未完全理解.
  • 上空气道和下空气道之间的微生物组成和功能的差异可能会影响宿主健康.

研究的目的:

  • 调查气道微生物群对宿主代谢的贡献.
  • 为了确定在上空气道和下空气道的微生物途径和代谢物的差异.
  • 探索口服食用素在塑造下呼吸道代谢环境中的作用.

主要方法:

  • 呼吸道样本的代谢分析.
  • 微生物组简介.微生物组简介.
  • 识别微生物代谢物和途径.

主要成果:

  • 在上空气道和下空气道之间观察到微生物代谢途径和代谢物的显著差异.
  • 包括Prevotella melaninogenica在内的口服食用动物被确定为下呼吸道代谢环境的关键贡献者.
  • 发现Prevotella melaninogenica在下呼吸道中合成了氨酸和谷氨酸.

结论:

  • 呼吸道微生物群在局部新陈代谢中起着重要作用.
  • 在上空气道和下空气道微生物组之间存在不同的代谢功能.
  • 特定的口服食用植物通过生产必需代谢物,为下呼吸道的代谢景观做出贡献.