注射性雌激醇单一疗法在性别确认激素治疗中有效抑制丸激素
Aaron L Misakian1, Danit Ariel2, Erika A Sullivan3
1Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia.
概括
注射性雌激醇有效地抑制跨性别和性别多样性个体的丸激素. 孕激素的使用进一步降低了丸激素,而螺旋乳没有显著的影响.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 跨性别者医疗保健 跨性别者保健
背景情况:
- 雌激素疗法用于跨性别和性别多元个体的女性化.
- 了解影响激素抑制的因素对于有效的激素治疗至关重要.
研究的目的:
- 为了评估注射性雌激素和血清总 (TT) 度之间的关联.
- 为了确定协同变量的影响,如给药方法,类型,注射时间和并发药物对TT水平的影响.
主要方法:
- 一项回顾性多站点研究分析了357名跨性别和性别多样性患者每周注射雌激素的数据.
- 权重线性混合模型评估了TT度与各种共变量之间的关系.
- 达到指南推的TT抑制 (<50 ng/dL) 的患者与没有达到指南的患者进行了比较.
主要成果:
- 注射性雌激醇单一疗法在82.6%的患者中实现了TT抑制.
- 较高的雌激醇度,注射后的时间缩短,以及孕激素使用与较低的TT相关.
- 在雌激素单一治疗和与抗雄激素或孕激素联合治疗之间没有观察到TT抑制的显著差异.
结论:
- 注射性雌激醇对跨性别和性别多样性个体的丸激素抑制有效,与组合疗法相似.
- 孕激素的使用独立地与较低的TT度有关.
- 在这个队列中,螺旋乳没有显示出对TT抑制的显著影响.
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