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超标蛋白和非编码RNA:解开它们在瘤微环境中的相互作用,用于向癌症治疗

Yongqing Xu¹, Jin Wang², Xin Deng³

¹Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Pharmacological research

|July 10, 2025

概括

脱化酶 (DUB) 和非编码RNA (ncRNA) 相互作用,影响癌症的进展和治疗耐药性. 针对这种USP-ncRNA轴,特别是通过纳米输送,为癌症提供了新的治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生化学

背景情况:

癌症是一个主要的全球健康挑战,其特点是细胞失调和复杂的瘤微环境 (TME).
由二化酶 (DUB) 调节的化和二化,是影响细胞过程的关键转录后修饰.
DUBs的相互作用,特别是泛素特异蛋白酶 (USPs) 和非编码RNA (ncRNAs) 显著影响癌症的发展和异质性.

研究的目的:

审查癌症中USP和ncRNA之间的复杂相互作用.
探索这些相互作用如何影响关键癌症特征和TME.
突出针对USP-ncRNA轴在癌症治疗中的治疗潜力.

主要方法:

在癌症中调查USP-ncRNA相互作用的研究的文献综述.
分析USP和ncRNA在癌症特征中的作用,如扩散,亡,转移和血管生成.
检查对TME内代谢重编程和免疫调节的影响.

主要成果:

USP和ncRNA共同调节癌细胞的增殖,细胞亡,转移,血管新生和干细胞.
USP-ncRNA轴影响TME内的代谢重编程和免疫逃避.
特定USP-ncRNA相互作用的失调有助于癌症的攻击性和治疗耐药性.

结论:

USP与ncRNA之间的复杂关系为癌症提供了一个新的治疗点.
准USP-ncRNA轴有望克服对传统癌症疗法的耐药性.
将纳米技术输送系统与USP-ncRNA向疗法的整合可以提高治疗效率.

关键词:

免疫调节免疫调节代谢重编程是一种代谢重编程.纳米技术纳米技术非编码RNAs (ncRNAs) 是一种非编码RNA.针对性抑制抑制的目标.乌比基特异性蛋白酶 (USP) 是一种

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