在药物发现中转化PBPK/PD建模:CRO视角
Simone Esposito1, David Cebrián1
1Integrated Drug Discovery, Selvita SA, Podole 79, 30-394 Kraków, Poland.
转化生理学基础的药理动力学和药理动力学 (PBPK/PD) 建模通过整合数据和优化资源使用来增强药物发现. 这种方法改善了赞助商和合同研究组织 (CRO) 之间的合作.
科学领域:
- 药理学和药物发现
- 计算生物学 计算生物学
- 临床前研究 临床前研究
背景情况:
- 基于生理学的药理动力学和药理动力学 (PBPK/PD) 建模是现代药物发现的组成部分.
- 这些模型促进了先进的数据集成,考虑了特定物种的生理学和向药理学.
- 在综合药物发现 (IDD) 合作中,PBPK/PD的应用正在扩大.
研究的目的:
- 介绍临床前合同研究组织 (CRO) 对翻译PBPK/PD建模的观点.
- 概述IDD中这些建模方法的应用,好处和挑战.
- 检查PBPK/PD对CRO中药物代谢和药理动力学项目代表 (DPR) 的作用的影响.
主要方法:
- 在临床前合同研究中审查PBPK/PD应用.
- 分析PBPK/PD对综合药物发现工作流程的影响.
- 在CRO-赞助商伙伴关系中展示PBPK/PD实施的案例研究或示例.
主要成果:
- 翻译PBPK/PD建模在数据集成和预测准确性方面提供了显著的优势.
- 挑战包括数据可用性,模型复杂性和监管接受度.
- 据了解,DPR的作用已经演变,包括先进的建模和数据解释技能.
结论:
- 采用翻译PBPK/PD方法可以加强赞助商和CRO的合作关系.
- 这些方法在整个药物发现过程中促进了数据驱动的决策.
- 优化资源利用和改进项目成果是关键优势.
更多相关视频
08:49Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
Published on: June 20, 2025
22:10Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
Published on: June 28, 2013
相关概念视频
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
A recent model describes pravastatin's hepatobiliary excretion,...
Physiological Pharmacokinetic Models: Assumption with Protein Binding
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Drug Discovery: Overview
Pharmacokinetic Models: Overview
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
