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发酵的羊奶酪 Lactococcus lactis 增强骨健康,减少骨质疏松性骨质损失
Shuo Liu1, Chenyu Li1, Yang Lv2
1Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, the College of Life Sciences, Northwest University, Xi'an 710069, China.
乳球菌 Lactococcus lactis 3-1,是一种新型益生菌菌株,通过增强骨质生成和改善骨密度,促进骨健康. 发酵成山羊奶酪,它为骨质疏松症管理提供了一个有前途的自然疗法.
科学领域:
- 微生物学 微生物学
- 骨生物学 骨生物学 骨生物学
- 营养科学 营养科学
背景情况:
- 骨质疏松症是一个日益严重的公共卫生问题,特别是在老年人群中.
- 目前的骨质疏松症治疗有局限性,需要更安全,更有效的替代方案.
- 益生菌显示出对骨健康的潜力,但特定的菌株和输送方法需要进一步调查.
研究的目的:
- 为了识别和表征一种新的益生菌菌株,以促进骨健康.
- 为了评估Lactococcus lactis 3-1发酵山羊奶酪作为骨质疏松症的功能性食物的有效性.
- 为了评估这种益生菌发酵奶酪对骨微观架构和机械特性在骨质疏松病鼠模型的影响.
主要方法:
- 在实验室中对乳球菌乳酸菌3-1进行骨质性基因表达和骨质前细胞分化的分析.
- 用L. lactis发酵的山羊奶酪的开发和感官评估 3-1.
- 在体内研究,使用使用L. lactis 3-1发酵山羊奶酪治疗的废弃诱导的骨质疏松性大鼠.
- 微型计算机断层扫描 (微型CT) 和机械测试以评估骨参数.
主要成果:
- 乳球菌乳酸菌3-1显示出高酸盐的产生和对关键的骨质基因 (RUNX2,BGLAP,ALP) 的上调.
- 发酵的山羊奶酪表现出最佳的质地和口感.
- 在患有骨质疏松症的老鼠中,L. lactis 3-1奶酪显著改善了骨矿物质密度 (74.88%的增加),状骨架构和机械强度,同时减少了骨再吸收标志物.
结论:
- 乳球菌乳酸菌3-1是一种强大的促进骨健康的益生菌菌株.
- L. lactis 3-1-发酵山羊奶酪是骨质疏松症干预的可行和有效的功能性食品.
- 这种基于益生菌的方法为治疗骨质疏松症提供了一个可持续的策略.
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