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识别 papilledema 和伪 papilledema 的生物标志物

Rishi Sekhri¹, Helen J Kuht¹, Zhanhan Tu¹

¹Ulverscroft Eye Unit, School of Psychology and Vision Sciences, College of Life Sciences, University of Leicester, Leicester, UK.

Scientific reports

|July 10, 2025

概括

光学一致性断层扫描 (OCT) 可以使用特定的生物标志物来区分 papilledema 和伪 papilledema. 这种非侵入性成像工具有助于诊断视神经头部胀并预防视力损失.

科学领域:

眼科医生眼科眼科
神经学神经学
医疗成像医学成像

背景情况:

乳头,视神经头部 (ONH) 由于内压力增加而胀,可能导致视力丧失.
从临床上来说,区分 papilledema 和 pseudopapilledema 是具有挑战性的,可能需要进行侵入性手术.
光学一致性断层扫描 (OCT) 提供了一种非侵入性方法来可视化ONH.

研究的目的:

为了识别OCT衍生的生物标志物,以区分 papilledema 和伪 papilledema.
评估这些生物标志物的诊断性能,以区分皮皮瘤与光盘干燥 (ODD),倾斜光盘 (TOD) 和拥挤的光盘 (COD).

主要方法:

文献审查以确定OCT生物标志物用于乳腺炎和伪乳腺炎.
分析了来自213名确诊患有 papilledema,ODD,TOD或COD的患者的OCT扫描.
使用后勤回归模型计算单个和组合生物标志物的灵敏度,特异性和AUC.

主要成果:

一个使用定性生物标志物的模型从ODD和COD中区分了 papilledema,灵敏度为89%,特异性为89%,AUC为0.96.
在模型中包括TOD,使灵敏度降低到66%.
一个单独的模型区分 papilledema 和 TOD 显示了一个表现最好的生物标志物,灵敏度为87%,特异性为61%,AUC为0.83.

结论:

通过使用定性生物标志物来区分ODD和COD的 papilledema,OCT显示出显著的实用性.
定量生物标志物在区分TOD和乳头炎症方面表现有前途.
超越国土和地区作为一种有价值的非侵入性工具,用于区分 papilledema 和各种形式的伪 papilledema.

关键词:

拥挤的光学光盘.光学磁盘的磨损是因为光盘的磨损.光学连贯性断层扫描仪纸发的情况伪皮囊性瘤是什么倾斜的光学光盘是倾斜的光盘.

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