原生乳杆菌和Bifidobacterium益生菌调节自基因并产生抗炎作用
Fatemeh Haririzadeh Jouriani1, Mahdi Torkamaneh1, Mahnaz Torfeh1
1Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Scientific reports
|July 10, 2025
概括
原生益生菌增强自基因表达并减少炎症,为炎症性疾病提供潜在的预防性治疗. 这些有益的微生物在炎症发作之前表现出更强烈的作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 益生菌是有益的微生物,已知会影响宿主信号通路.
- 自在细胞平衡和炎症反应中起着至关重要的作用.
- 了解炎症期间亲生菌介导的自细胞调节对于治疗的发展至关重要.
研究的目的:
- 研究乳酸菌种,双菌种和原生益生菌混合物对自信号传递的分子作用.
- 在炎症的背景下,评估益生菌对自基因表达的影响.
- 评估原生益生菌在炎症诱导之前和期间的抗炎潜力.
主要方法:
- HT-29 细胞系暴露于超声波病原体和益生菌.
- 使用特定药物诱导炎症.
- 定量实时聚合酶连锁反应 (qPCR) 用于自基因表达分析.
- 细胞因子测定用于测量炎症标志物.
主要成果:
- 与病原体治疗相比,原生益生菌尾酒显著提高了自基因 (pik3c3, atg14, beclin, pik3r4, atg5, atg16, atg7, atg3) 的调节.
- 益生菌表现出抗炎作用,特别是在炎症诱导前服用时.
- 益生菌对自基因的调节在炎症发生之前比与炎症刺激联合使用时更明显.
结论:
- 原生益生菌配方表现出对炎症的预防和治疗作用.
- 益生菌在炎症前进行预防时,对自基因的影响更大.
- 益生菌可以被视为一种安全有效的预防性治疗炎症状况,特别是当在炎症过程的早期使用时.
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