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Updated: Sep 16, 2025

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
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Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

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对软骨组织中单细胞水平上的软骨细胞种群的洞察

Csaba Matta1, Roland Takács1, Mona Dvir-Ginzberg2

  • 1Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Nature reviews. Rheumatology
|July 10, 2025
PubMed
概括

单细胞多组学揭示了软骨细胞亚型,进步了对软骨健康和疾病的理解. 这一突破使得针对性治疗骨关节炎和再生疗法成为可能.

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Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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