对间歇性禁食的反应性二态化及其对大脑的影响
Keshari H Sudasinghe1, Zachary J White1, Stephanie E Hall2
1Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 1620 Denison Ave. Coles Hall 228, Manhattan, KS, 66506, USA.
Scientific reports
|July 10, 2025
概括
间歇性禁食 (IF) 改善了雄性大鼠的记忆,并降低了mTOR信号,但不是雌性大鼠. 这项研究表明IF是IF.
科学领域:
- 神经科学是一个神经科学.
- 代谢过程中的代谢.
- 衰老研究研究 衰老研究
背景情况:
- 间歇性禁食 (IF) 显示了增强认知功能的前景,特别是在动物模型中.
- 已知IF可以降低哺乳动物目标的拉帕素 (mTOR) 表达,这是一个关键的信号通路.
- 了解IF对认知和mTOR信号传递的影响对于潜在的治疗应用至关重要.
研究的目的:
- 研究间歇性禁食 (IF) 对雄性和雌性大鼠的记忆力,强度和mTOR信号传递的影响.
- 为了确定IF诱导的mTOR信号的变化是否与认知改善相关.
- 探索潜在的性别特异性差异对IF的反应.
主要方法:
- 10周大的雄性和雌性Fischer-344大鼠被分配到自由选择 (AL) 或IF组.
- 在IF组10周内,每隔一天食用食物.
- 评估了记忆力和力量,随后使用Jess Simple Western对mTOR通路蛋白进行了大脑和骨肌肉分析.
主要成果:
- 间歇性禁食导致身体质量和食物摄入量降低,仅在雄性大鼠中.
- 与对照组相比,接受IF治疗的雄性大鼠表现出更好的记忆性能.
- IF在两性中都减少了大脑质量,但保留了海马体质量,在雄性大鼠皮质和骨肌肉中减少了mTOR表达.
结论:
- 间歇性禁食有效地减少了雄性大鼠皮质和骨肌中的mTOR信号,与改善的记忆相关.
- 在男性中观察到IF对记忆和mTOR抑制的积极影响,但在女性中没有显著的影响.
- 需要进一步的研究,以阐明IF对认知功能和代谢途径的影响背后的性别特异性机制.
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