遗传预测的脚间距宽度与与年龄相关的骨矿物质密度风险之间的因果关系
Xian-Pei Xiao1, Yong-Jun Dai2, Hong-Xu Li2
1Department of Critical Care Medicine, Luojiang District People's Hospital of Deyang City, Deyang, 618000, Sichuan Province, China.
Scientific reports
|July 10, 2025
概括
脚间距宽度 (ASW) 与较低的骨矿物质密度 (BMD) 有因果关系,特别是在老年人中. 这一发现表明,ASW可以帮助监测与年龄相关的骨损失和骨质疏松症风险.
科学领域:
- 人类遗传学 人类遗传学
- 骨的新陈代谢 骨的新陈代谢
- 骨质疏松症研究 骨质疏松症研究
背景情况:
- 观察性研究表明,脚间距宽度 (ASW) 与骨质疏松症,骨折和跌倒之间存在联系.
- 这种关联的因果证据有限,这阻碍了ASW测量的临床应用.
- 了解ASW在骨健康中的因果作用对于风险分层至关重要.
研究的目的:
- 调查ASW指标与特定地点/特定年龄的骨矿物密度 (BMD) 之间的因果关系.
- 检查ASW与骨折和跌倒风险之间的因果关系.
- 探索ASW作为年龄相关骨质损失的潜在生物标志物.
主要方法:
- 使用双样本门德尔随机化 (TSMR) 和多变量门德尔随机化 (MVMR) 分析.
- 采用了来自MRC-IEU的ASW指标的遗传数据和来自GEFO联盟的结果数据.
- 使用仪器变量 (SNP) 来推断因果关系,并对BMI,吸烟和酒精进行调整.
主要成果:
- 增加的ASW与较低的估计BMD (eBMD) 和全身BMD (TB-BMD) 有因果关联,特别是在60岁以上的个体中.
- 在较年轻的年龄组或特定地点的骨折/跌倒中,没有发现ASW和TB-BMD之间的显著关联.
- MVMR证实了ASW和减少的eBMD和TB-BMD之间的持续因果关系,特别是60岁以上的人的TB-BMD.
结论:
- 基因预测的ASW与减少的eBMD和TB-BMD有关.
- 在60岁以上的个体中,ASW和减少的TB-BMD之间存在因果关系.
- ASW可以作为潜在的辅助生物标志物来监测年龄相关的骨损失和骨质疏松症风险.
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