前列腺癌患者前列腺动脉栓塞的有效性和安全性:系统性审查和元分析
Vanesa Lucas-Cava1, Francisco Miguel Sánchez-Margallo2, Fei Sun3
1Endoluminal Therapy and Diagnosis Unit, Jesús Usón Minimally Invasive Surgery Centre, Road N-521, Km 41.8, 10071, Cáceres, Spain. vlucas@ccmijesususon.com.
Cardiovascular and interventional radiology
|July 10, 2025
概括
前列腺动脉栓塞 (PAE) 和前列腺动脉化学栓塞 (PACE) 有效地管理前列腺癌 (PCa) 症状,成功率高,不良事件低. 这些微创治疗方法为寻求症状缓解的患者提供了安全的选择.
科学领域:
- 干预性放射学 干预性放射学
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 前列腺动脉栓塞 (PAE) 越来越多地用于管理前列腺癌 (PCa) 患者下尿路症状 (LUTS).
- PAE及其变体前列腺动脉化学栓塞 (PACE) 的有效性和安全性需要全面评估.
研究的目的:
- 在前列腺癌患者中进行元分析,评估PAE和PACE的有效性和安全性.
- 评估技术成功,临床疗效,瘤学结果和与这些程序相关的不良事件.
主要方法:
- 来自PubMed和Web of Science数据库的研究的系统审查.
- 在PCa患者中包括PAE或PACE的研究.
- 主要结局 (技术/临床成功,瘤疗效,不良事件) 和次要结局 (IPSS,QoL,PV,PSA) 的定量和定性分析.
主要成果:
- 分析了11项单臂研究,共151名参与者.
- 观察到高的技术 (95.53%) 和临床成功 (90.31%) 的汇总率.
- IPSS,QoL,前列腺体积和PSA的显著改善,轻微 (23.88%) 和重大 (0.6%) 副作用的发生率较低. 与PACE相比,PAE显示出较少不良事件的趋势.
- 瘤疗效为65.89%,研究表明存在高偏差风险.
结论:
- PAE和PACE是可行的,有效的和安全的微创治疗方法,用于控制前列腺癌患者的泌尿系统症状.
- 这些栓塞技术可以作为辅助疗法,并用于PCa的局部治疗.
- 需要进一步的研究,以解决包含的研究中发现的偏差高风险.
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