在伊朗大脑成像数据库中使用ADNI数据验证无痴呆症状态:从中年到老年成年人的过渡点
Sadegh Ghaderi1,2, Sana Mohammadi3, Farzad Fatehi3
1Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. s_ghaderi@razi.tums.ac.ir.
BMC neurology
|July 10, 2025
概括
伊朗脑成像数据库 (IBID) 提供经过验证的神经成像数据,有效地区分了没有痴呆症的人与阿尔茨海默病 (AD) 患者. 这些数据对于理解正常衰老与痴呆症进展至关重要.
科学领域:
- 神经成像是一种神经成像.
- 老年学是一门学科.
- 神经学 神经学
背景情况:
- 伊朗大脑成像数据库 (IBID) 要求对老年人无痴呆症状态进行验证.
- 将IBID数据与阿尔茨海默病神经成像计划 (ADNI) 的数据进行比较,对于阿尔茨海默病 (AD) 患者的验证至关重要.
研究的目的:
- 在55岁以上的成年人中验证IBID无痴呆状态.
- 为了比较IBID和ADNI队列之间的痴呆症概率指标.
主要方法:
- 横截面研究比较41名认知正常的IBID参与者 (年龄大于55岁) 与41名年龄/性别匹配的ADNI的ADN患者.
- 使用AssemblyNet-AD (volBrain) 处理的3D T1加权MRI数据,用于分级和缩得分 (HAVA).
- 非参数的曼-惠特尼U测试和定量回归分析了群体差异和缩关联.
主要成果:
- 与ADNI相比,IBID参与者表现出明显较低的痴呆症概率 (0.20%对99.93%) 和区域缩 (HAVAs:14.76对86.41) .
- 量子回归证实了稳定的海马体贡献,并增加了与较高缩严重程度的群体差异.
结论:
- 从IBID获得的经验证的无痴呆症神经成像数据可以可靠地区分正常衰老和痴呆症-AD状态.
- IBID是研究认知衰老和神经退行性疾病的宝贵资源.
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