中年和老年中国成年人修改的甘油三指数与中风风险之间的关联:一项前性队列研究
Jiaan Sun1, Xianglong Meng1, Lichun Guo1
1Zhengzhou University Affiliated Zhengzhou Central Hospital, Zhengzhou, 450007, China.
Cardiovascular diabetology
|July 10, 2025
概括
修改的甘油三和葡萄糖 (TyG) 指数,如TyG-BMI,TyG-WC和TyG-WHtR与中年和老年人中风风险增加有关. 控制体重和腰围可以帮助降低这种风险.
科学领域:
- 心血管流行病学心血管流行病学
- 代谢综合征研究研究
- 预测中风风险的预测
背景情况:
- 甘油三和葡萄糖 (TyG) 指数是胰岛素耐药性的标志物.
- 修改的TyG指数,包括TyG-BMI,TyG-WC和TyG-WHtR,已经成为心血管事件的潜在预测因素.
- 关于这些修改后的TyG指数对发生中风的预测能力的研究有限.
研究的目的:
- 调查修改的TyG指数 (TyG-BMI,TyG-WC,TyG-WHtR) 与发生性中风风险之间的关联.
- 为了比较这些修改的TyG指数对中风的预测能力,在一个大型,全国代表的队列中.
主要方法:
- 一项前性队列研究,利用来自中国健康与退休纵向研究 (CHARLS) (2011-2018) 的纵向数据.
- 包括8677名参与者;分析了使用Cox比例风险模型,限制立方线 (RCS) 和接收器操作特征 (ROC) 曲线的协会.
- 进行敏感性和子组分析以验证发现.
主要成果:
- 在随访期间,807名参与者 (9.3%) 患有中风.
- 增加的TyG-BMI,TyG-WC和TyG-WHtR在多因素调整后与更高的中风风险显著相关.
- TyG-WHtR显示出线性剂量-反应关系,而TyG-BMI和TyG-WC显示出与中风风险的非线性关系. 所有指数都表现出可比的预测能力,而TyG-WC略高.
结论:
- 修改的TyG指数 (TyG-BMI,TyG-WC,TyG-WHtR) 与中年和老年人中中风风险呈正相关性.
- 这些指数可以作为评估中风风险的有价值工具.
- 建议进行体重和腰部管理,以通过改善这些代谢标志物来潜在地减轻中风风险.
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