cGAS-STING通路:在癌症中免疫反应的双重调节者和治疗影响
Zhanghao Huang1,2,3, Jun Zhu2,3, You Lang Zhou1,4
1Medical School of Nantong University, Nantong University, Nantong, 226001, China.
Journal of translational medicine
|July 10, 2025
概括
循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径在癌症免疫中具有双重作用,促进抗瘤反应,同时也使免疫逃避. 了解这种平衡对于开发新的癌症疗法至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径对于先天免疫,检测细胞质DNA和启动炎症反应至关重要.
- 这种途径在癌症中起着复杂的作用,影响抗瘤免疫和免疫逃避机制,如PD-L1上调.
- 诸如自,氧化应激和DNA损伤等因素调节cGAS-STING信号传递,影响瘤进展和宿主防御.
研究的目的:
- 阐明cGAS-STING通路在癌症免疫和进展中的多方面的作用.
- 探索细胞过程如自和翻译后修饰如何影响cGAS-STING活动.
- 确定治疗策略,利用cGAS-STING的免疫刺激潜力,同时克服免疫抑制.
主要方法:
- 关于癌症中cGAS-STING通路信号传导的现有文献的审查和综合.
- 分析cGAS-STING,自,DNA损伤和免疫检查点之间的相互作用.
- 对影响cGAS-STING功能的翻译后修改 (例如m6A甲基化,乙化) 的研究.
主要成果:
- 该cGAS-STING通路表现出双重功能,促进抗瘤免疫力,但也通过PD-L1.1驱动免疫逃避.
- 自和相分离增强cGAS信号,影响瘤增殖和DNA传感.
- 氧化应激和DNA损伤激活cGAS-STING,导致炎症和潜在的代谢障碍.
- 针对DNA损伤反应和免疫检查点的综合疗法显示,增强抗瘤免疫力是有希望的.
- 翻译后修改微调cGAS-STING活动和下游信号.
结论:
- 由于其双重的亲和抗瘤作用,cGAS-STING通路在癌症中呈现出复杂的治疗标.
- 有针对性的干预措施可以利用cGAS-STING的免疫刺激作用,同时减轻免疫逃生机制.
- 该途径与炎症和代谢功能障碍的联系突出了其超出癌症范围的更广泛的临床相关性.
更多相关视频
09:04Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
705
07:41A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
9.0K
相关概念视频
Interactions Between Signaling Pathways
6.5K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.5K
Regulation of Hematopoietic Stem Cells
3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Tumor Immunotherapy
665
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
665
The JAK-STAT Signaling Pathway
9.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.3K
Amplifying Signals via Enzymatic Cascade
9.1K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
9.1K
