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Updated: Sep 16, 2025

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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在类风湿性关节炎中,JAK-STAT信号传递和颗粒细胞-巨细胞殖民地刺激因子在骨质炎和骨微观结构变化的发展中的作用

Tsuneyasu Yoshida1,2, Yoshiki Murotani3, Koichi Murata3,4

  • 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Arthritis research & therapy
|July 10, 2025
PubMed
概括

颗粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 通过促进骨质细胞分化,驱动早期关节炎变化,如骨炎和骨微观结构变化. 向GM-CSF可能会防止类风湿性关节炎 (RA) 的放射性进展.

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