一项随机对照性可行性试验的研究协议,用于治疗情绪双极症状 (STABILISE) 的行为疗法
Kim Wright1, Fiona Warren2, Sandra Bucci3,4
1Department of Psychology, University of Exeter, Exeter, UK. K.A.Wright@ex.ac.uk.
Pilot and feasibility studies
|July 10, 2025
概括
这项可行性研究评估了STABILISE治疗双相情感障碍之间的情节间症状. 结果将指导最终的试验,评估治疗安全性,招募和收集情绪稳定的数据.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 行为治疗是一种行为疗法.
背景情况:
- 双极性障碍患者在发作之间经历情绪不稳定.
- 循环心律障碍还涉及情绪波动.
- 适应性行为疗法 (STABILISE) 被评估为插曲症状.
研究的目的:
- 评估STABILISE治疗的可行性和可接受性.
- 为了评估未来的最终试验的研究程序.
- 收集数据进行经济成分分析.
主要方法:
- 随机对照试验比较了STABILISE加通常治疗 (TAU) 与单独TAU.
- 招募60名患有双极性谱系障碍和持续症状的个人.
- 通过招聘/保留率,结果测量完成 (PHQ9,ALS-SF,QOL.BD,BRQ) 和参与者反来评估可行性.
主要成果:
- 可行性取决于安全性,招聘率 (≥2/月/地点) 和30周结果数据的可用性 (≥75%或55-74%与改进计划).
- 通过参与者对治疗和研究程序的反来评估可接受性.
- 经济部分的可行性也得到了检查.
结论:
- 这项随机对照可行性试验为STABILISE治疗提供了明确的试验信息.
- 这些发现将改进研究程序和治疗方案.
- 这项研究为大规模研究跨情节双极性症状管理奠定了基础.
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