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怀孕期间体重增加和围产死亡风险:系统性审查和元分析

Yu Tang¹, Nabil Islam², Rong Luo^3,4

¹School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.

Obesity reviews : an official journal of the International Association for the Study of Obesity

|July 11, 2025

概括

过度的妊娠间体重增加 (IPWG) 显著增加了围产死亡,死产和新生儿死亡的风险. 这凸显了在怀孕期间进行体重管理咨询的迫切需要,以改善母亲和婴儿的结果.

科学领域:

生殖健康生殖健康
围产儿医学围产儿医学
流行病学流行病学

背景情况:

怀孕期间体重增加 (IPWG) 和围产死亡率之间的关联需要进一步澄清.
了解这种联系对于优化怀孕之间母亲和婴儿健康结果至关重要.

研究的目的:

进行一项元分析,研究怀孕期间体重指数 (BMI) 增加对围产死亡率的影响.
量化与IPWG相关的围产死亡,死胎和新生儿死亡风险.

主要方法:

在2024年7月,对MEDLINE,Embase,Cochrane图书馆和Web of Science进行了系统的搜索.
包括报告IPWG (≥2个BMI单位或类别变化) 和围产死亡率的观察性研究.
随机效应的元分析被用来组合调整的几率比率 (aOR) 和95%置信区间 (CI).
使用ROBINS-I工具评估了偏差风险.

主要成果:

分析包括10项研究,涵盖3,072,698例怀孕.
怀孕期间体重增加 (IPWG) 与产周死亡风险增加有显著关联 (aOR,1.49;95% CI,1.32-1.69).
此外,IPWG还增加了死产 (aOR,1.46;95% CI,1.23-1.72) 和新生儿死亡 (aOR,1.39;95% CI,1.19-1.61) 的风险.

结论:

妊娠期间体重增加 (IPWG) 是产周期不良结果的重要风险因素,包括产周期死亡,死胎和新生儿死亡.
这些发现强调了体重管理咨询在怀孕期间的重要性,以减轻风险.
进一步的研究可能会探索促进健康妊娠期间体重轨迹的干预措施.

关键词:

产前死亡产前死亡怀孕间隔怀孕间隔的时间体重增加体重增加

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