相关实验视频

Updated: Sep 16, 2025

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity AIDN: A Translational Neuroscience Approach

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity AIDN: A Translational Neuroscience Approach

Published on: June 11, 2017

在婴儿猪的局部麻醉后,用囊素改善养功能的机制

Chloe E Edmonds¹, Kaitlyn N Robbins^1,2, Elizabeth G Dvorak¹

¹Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA.

The Laryngoscope

|July 11, 2025

概括

下膜神经 (IAN) 的麻醉降低了婴儿养效率,但改善了呼吸道保护. 素部分恢复了食功能,这表明它可能有助于一些,但不是所有的,食障碍病例.

科学领域:

婴儿养生理学婴儿养生理学
感觉和运动控制的神经科学.
吞障碍 (吞障碍) 的发生.

背景情况:

感官缺陷会对食产生负面影响,而感官刺激可以增强食.
素是一种感官刺激剂,可改善成年人的吞能力,并影响婴儿动物的食.
下膜神经 (IAN) 在口腔感觉和运动控制中起作用,与食有关.

研究的目的:

调查下膜神经 (IAN) 在婴儿养中的作用.
为了确定素是否可以逆转或补偿因IAN麻醉引起的食缺陷.
在婴儿模型中评估IAN麻醉和素对吞生理学的影响.

主要方法:

在婴儿猪模型中使用了同时进行视频光学和电肌学 (EMG) 的方法.
量化吞频率,每次吞的吸血量,每次吸血的牛奶摄入量,球体大小和呼吸道损害.
测量了舌头和甲状腺软骨的外出,以及消化道,神经和甲状腺肌肉活动.

主要成果:

IAN麻醉降低了养效率 (减少吞频率,每次吸入的牛奶,球体大小;增加每次吞的吸入量).
通过IAN麻醉改善了呼吸道保护,并改变了舌头的外流.
素部分恢复了一些养变量,但没有完全扭转IAN麻醉缺陷.

结论:

IAN麻醉在降低食效率和增强呼吸道保护之间进行了权衡.
素会影响食生理,但并不能普遍扭转与感官相关的食缺陷.
素可能是特定类型的消化障碍的潜在治疗剂,但不适用于所有人.

关键词:

卡普赛辛是一种素.脱质障碍脱质障碍是一种脱质障碍.失足症是一种失足症.电动肌谱学电动肌谱学婴儿养婴儿养耳鼻的动力学儿科儿科儿科儿科传感器-运动器集成.

更多相关视频

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets

Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets

Published on: December 19, 2019

相关概念视频

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

Local Anesthetics: Pharmacokinetics

Local Anesthetics: Pharmacokinetics

The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...