Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

532
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
532
Incomplete Dominance01:43

Incomplete Dominance

25.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
25.6K
Bias01:22

Bias

5.0K
Bias refers to any tendency that prevents a question from being considered unprejudiced. In research, bias occurs when one outcome or answer is selected or encouraged over others in sampling or testing. Bias can occur during any research phase, including study design, data collection, analysis, and publication.
In statistics, a sampling bias is created when a sample is collected from a population, and some members of the population are not as likely to be chosen as others (remember, each member...
5.0K
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

697
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
697
Genetic Variation01:25

Genetic Variation

396
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
396
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Heritable Genetic Effects Caused by a Single Generation of Captive Breeding.

Evolutionary applications·2026
Same author

Where We Go From Here: Harnessing Queer Perspectives to Advance Practice in Ecology and Evolutionary Biology.

Ecology and evolution·2026
Same author

There is No Consensus on Biological Sex.

Ecology letters·2026
Same author

Seven draft genomes for halophilic bacteria from samples in Northern California.

Microbiology resource announcements·2026
Same author

Unbiased comparison of the number of segregating sites across unequal sample sizes.

The Journal of heredity·2026
Same author

A phylogeny for genus Capra based on extensive sampling of wild populations.

PloS one·2025

相关实验视频

Updated: Sep 16, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.1K

"高度信息化的"遗传标记可以偏见结论:例子和一般解决方案.

Andy Lee1, William Hemstrom1,2, Natalie Molea3,4

  • 1Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.

Molecular ecology resources
|July 11, 2025
PubMed
概括
此摘要是机器生成的。

高等级偏差,从选定的遗传标记中高估人口结构,可以误导保护工作. 使用统计异常值测试或换测试可以帮助检测和预防遗传研究中的这种偏差.

关键词:
生态遗传学 生态遗传学这是基因组学/蛋白质组学.自然选择和当代进化人口遗传学理论上的遗传学.

更多相关视频

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.9K

相关实验视频

Last Updated: Sep 16, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.1K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.9K

科学领域:

  • 人口遗传学 人口遗传学
  • 基因组数据分析 基因组数据分析
  • 保护科学 保护科学

背景情况:

  • 高分级偏差是由模型过拟合引起的,导致在选定的遗传位点中过度估计的功率.
  • 这种偏差发生在高度信息或高FST标记被选择并重新用于后续分析时,这是人口遗传学中常见的做法.
  • 这个问题甚至可以在没有本地适应的泛米种群中出现,可能会影响保护策略.

研究的目的:

  • 为了证明高等级偏差如何严重高估人口结构.
  • 突出对保护的潜在下游影响,包括保护单位的错误划分.
  • 引入检测和防止遗传数据集中的高分级偏差的方法.

主要方法:

  • 对实证和模拟数据集的分析,以识别高等级偏差.
  • 评估标志物确定策略,包括基于FST的选择.
  • 展示替代方法,如基于统计的异常值测试,排列测试和偏差检测的交叉评估.

主要成果:

  • 高等级偏差可能导致人口结构的严重高估,即使没有真正的差异化.
  • 选择高FST标记物的做法可以导致虚假的种群结构,影响保护决策.
  • 基于统计的异常值测试,排列测试和交叉评估被证明是有效的减少或检测高分级偏差.

结论:

  • 高度偏差是人口遗传研究中的关键问题,可能导致有缺陷的保护行动.
  • 研究人员在使用标记子集时应谨慎,特别是那些被选择用于高分化的标记子集.
  • 提供R包PCAssess,以帮助研究人员通过自动化分析检测和减轻高等级偏差.