结节边缘区域淋巴瘤在诊断时同时发生转变,并作为初始呈现的多发性输液:一个病例报告
Konstantinos Dodos1, Vasileia Tsampika Kalamara1, Vasiliki Epameinondas Georgakopoulou2
1Laboratory of Physiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Acta medica Lituanica
|July 11, 2025
概括
节点边缘区域淋巴瘤 (NMZL) 即使在诊断时也可以转化为攻击性的扩散型大B细胞淋巴瘤 (DLBCL). 这种罕见的呈现突显了诊断方面的挑战和早期分化需要,特别是在像多流液这样的非典型症状时.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 节点边缘区域淋巴瘤 (NMZL) 是一种罕见的,惰的B细胞非霍奇金淋巴瘤.
- 可以发生转变为攻击性的亚型,例如扩散型大B细胞淋巴瘤 (DLBCL).
- 在NMZL中,非典型的表现,如外流,是不常见的.
研究的目的:
- 报告一个罕见的NMZL病例,在诊断时转变为DLBCL.
- 突出NMZL的诊断挑战,特别是那些有异常症状的人.
- 强调早期差异化对患者预后和治疗的重要性.
主要方法:
- 一个67岁的女性患者的病例报告.
- 诊断程序包括细胞学和免疫组织化学.
- 组织病理学分析对于差异诊断至关重要.
主要成果:
- 患者在初始呈现时被诊断为NMZL转化为DLBCL.
- 发现了不典型的干咳和多流的症状.
- 免疫组织化学证实了单克隆B淋巴细胞和与转化一致的标记.
结论:
- 在诊断时必须考虑NMZL转变为DLBCL,尽管很少发生.
- 由于缺乏NMZL的特定标志物,因此需要进行基因病理学评估.
- 早期检测和分化淋巴瘤与多发性输液对于有效的管理至关重要.
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