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SIADH作为嗅觉神经母细胞瘤的不常见表现:基于病例的概述

Solene Papart¹, Adrian F Daly², Elettra Bianchi³

¹Department of Opthalmology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.

Endocrine oncology (Bristol, England)

|July 11, 2025

概括

嗅觉神经母细胞瘤 (ONB) 是一种罕见的鼻瘤,可以导致SIADH和低血症. 一个案例突出显示了68Ga-DOTANOC PET-CT.

科学领域:

神经瘤学神经瘤学
内分泌学在内分泌学.
诊断成像诊断成像诊断成像

背景情况:

嗅觉神经母细胞瘤 (ONB) 是一种罕见的恶性神经外皮瘤,起源于鼻腔.
ONB通常表现为鼻腔阻塞和表,但很少会导致SIADH,导致低血症.
与ONB相关的瘤性SIADH不常见,约发生在2%的病例中.

研究的目的:

报告一种仅表现为SIADH和低血的嗅觉神经母细胞瘤病例.
为了强调68Ga-DOTANOC PET-CT在识别隐藏的ONB的诊断实用性.
强调在不明原因的SIADH案件中考虑ONB的重要性.

主要方法:

研究了一名42岁的女性,她患有周期性低血和SIADH.
标准成像 (CT,FDG PET-CT) 无法识别瘤的来源.
68Ga-DOTANOC PET-CT检测出一种隐形病变在肌部,经外科手术后确认为ONB.

主要成果:

一个海姆斯等级1的ONB被诊断在ethmoid鼻.
患者的SIADH和低血症在手术切除瘤后完全消失.
68Ga-DOTANOC PET-CT证明在检测其他隐藏的神经内分泌瘤方面至关重要.

结论:

隐藏的ONB应考虑在不明原因SIADH的患者,特别是当初始工作结果是负的.
68Ga-DOTANOC PET-CT是检测神经内分泌瘤的宝贵工具,包括ONB.
迅速的手术干预对于终极治疗和解决瘤综合征至关重要.

关键词:

一个SIADH的SIADH.这是一个神经母细胞瘤.低血症是指低血症.嗅觉神经母细胞瘤是一种神经母细胞瘤.这是一种神经新陈代谢 (paraneoplastic).

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