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周围血液中T细胞子集的改变动态会影响新诊断的多发性骨髓瘤的疾病进展

Mohini Vig^1,2, Lalit Kumar², Shweta Dubey¹

¹Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India.

Biochemistry and biophysics reports

|July 11, 2025

概括

新诊断的多发性骨髓瘤 (MM) 患者显示T细胞数量减少和T细胞子集受损,包括调节性T细胞 (Tregs) 和循环T毛囊辅助细胞 (cT_FH). 这些免疫干扰可能会推动MM的进展.

科学领域:

免疫学免疫学免疫学
血液学血液学血液学
在瘤学瘤学.

背景情况:

T细胞对于免疫反应对抗瘤和调节多发性骨髓瘤 (MM) 等疾病至关重要.
在MM的发展和进展中T细胞的具体作用仍然不完全理解.

研究的目的:

调查新诊断MM (NDMM) 患者的T细胞中的活化状态,原始和记忆群体的分布,调节性T细胞 (Tregs) 和循环的T毛囊辅助细胞 (cT_FH).
评估NDMM患者T细胞上抑制受体 (CD160,ICOS,CTLA-4,PD-1) 的表达.
探索MM中T细胞变异和疾病进展标志物之间的关系.

主要方法:

在40名新诊断的MM患者和健康对照者的外周血液中分析T细胞子集,包括Tregs和cT_FH.
对周围血液T细胞的抑制受体表达 (CD160,ICOS/CD278,CD152/CTLA-4,PD-1/CD279) 的评估.
骨髓血细胞负担与外围T细胞特征之间的相关性分析.

主要成果:

与健康对照组相比,新诊断的MM患者的T细胞总数减少.
在原始和效应性CD4+T细胞之间观察到不平衡,同时在NDMM患者的记忆Tregs下降.
周围血液中激活的CT_FH细胞和表达抑制受体的T细胞的百分比增加与骨髓等离子体细胞水平相关.

结论:

新诊断的MM与T细胞平衡的显著干扰有关,包括T细胞数量的减少和T细胞子集分布的改变.
观察到Tregs的减少和激活cT_FH和抑制受体表达T细胞的增加表明MM的免疫失调.
这些T细胞变化和免疫媒介过程被认为是新诊断的MM中疾病进展的潜在驱动因素.

关键词:

细胞毒性T细胞毛囊辅助T细胞毛囊辅助T细胞辅助性T细胞可以帮助新诊断的多发性骨髓瘤监管性T细胞是什么意思 T细胞耗尽的情况.

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