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TBC1D1的预后价值及其与胰腺癌瘤微环境的关系:基于单细胞测序的研究

Linfeng Yang^1,2, Duan Yan^1,2, Jun Yu¹

¹Affiliated Hospital of North Sichuan Medical College Nanchong China.

FASEB bioAdvances

|July 11, 2025

概括

TBC1域家族成员1 (TBC1D1) 是胰腺癌 (PC) 的独立预后风险因素. 它的表达与瘤微环境相关,影响患者的生存.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
免疫学免疫学免疫学

背景情况:

TBC1域家族成员1 (TBC1D1) 涉及各种癌症,但其在胰腺癌 (PC) 中的作用尚不清楚.
了解TBC1D1在PC中的功能对于开发向疗法至关重要.

研究的目的:

为了研究TBC1D1在胰腺癌的预后价值.
探索TBC1D1表达与PC中的瘤微环境 (TME) 之间的关联.

主要方法:

使用免疫组织化学 (IHC) 和单细胞RNA测序 (scRNA-seq).
在168名PC患者中分析了TBC1D1的表达.
评估TME组件与TBC1D1水平相关.

主要成果:

在PC患者中,TBC1D1阳性被确定为PC患者整体存活 (OS) 的独立不良预后因素 (p=0.026).
TBC1D1表达与纤维细胞激活蛋白,PD-1和PD-L1.1正相关.
TBC1D1表达与CD8+ T细胞呈负相关性.

结论:

TBC1D1作为胰腺癌的显著预后风险因素.
TBC1D1可能通过影响瘤微环境,包括免疫细胞透和树皮成分来推动PC进展.

关键词:

TBC1域名家族成员1 与癌症相关的纤维细胞.胰腺癌是一种癌症.预后因素是一个预后因素.瘤微环境是一个微环境.瘤透的淋巴细胞

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