Dendrobium officinale Kimura & Migo花的黄酸对通过调节肠道微生物群对认知功能的影响
Nanzhi Hu1,2, Kaiyue Wang1, Xing Ge3
1Department of Geriatrics, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Frontiers in pharmacology
|July 11, 2025
概括
丹德罗比亚米花的花黄素 (DOFF) 通过改善肠道微生物群和减少神经炎症来对抗与衰老相关的认知衰退. 这项研究表明,DOFF增强了老年小鼠的肠道屏障功能和突触可塑性.
科学领域:
- 老年学和神经科学 在
- 微生物学和免疫学
背景情况:
- 衰老与认知能力下降有关,包括记忆和学习障碍.
- 神经炎症是年龄相关认知功能障碍的主要驱动因素.
- 丹德罗毕 (Dendrobium officinale) 的金村和米戈花的黄酸 (DOFF) 显示出调节肠道微生物群的潜力,并具有抗氧化和抗炎性质.
研究的目的:
- 在老化小鼠模型中研究DOFF对认知功能的影响.
- 探索DOFF的作用背后的机制,重点关注肠道微生物群的调节,神经炎症和突触可塑性.
主要方法:
- 使用D-银糖诱导老化小鼠模型.
- 给出了DOFF,并使用16SrDNA测序进行肠道菌群分析来评估其影响.
- 用Y迷宫测试来评估认知功能.
- 分析了肠道和大脑组织的炎症,氧化应激标志物和突触蛋白表达.
主要成果:
- DOFF干预调节了肠道微生物群的组成,增加了像阿克尔曼西亚这样的有益细菌,并降低了Firmicutes/Bacteroidetes的比率.
- DOFF改善了肠道屏障的完整性,并减少了结肠组织的损伤.
- 通过抑制促炎性细胞因子和微质激活,DOFF显著降低了氧化应激和神经炎症.
- DOFF治疗增加了突触蛋白表达和BDNF水平,增强突触可塑性和改善认知功能.
结论:
- 在D-银糖诱导的老化小鼠中,DOFF有效改善了认知功能障碍.
- DOFF通过调节肠道微生物群,加强肠道屏障和减轻神经炎症来发挥其有益作用.
- DOFF治疗减轻海马神经元损伤并改善突触可塑性,为与年龄相关的认知衰退提供了潜在的治疗策略.
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