定量抵抗的部署可以通过选择适应不良的病原体菌株来加强多年生植物的流行病
Jean-Paul Soularue1, Fabien Halkett2, Méline Saubin1
1Univ. Bordeaux, INRAE, BIOGECO Pessac France.
Evolutionary applications
|July 11, 2025
概括
部署几乎完全的植物耐药性有效控制流行病,并促进病原体的专业化. 然而,部分耐药性会导致不适应,可能会增加宿主死亡率和疾病严重程度.
科学领域:
- 植物病理学和进化遗传学
- 流行病学和人口动态.
背景情况:
- 定量耐药性对于农业系统中控制植物疾病至关重要.
- 病原体在应对抗药部署的进化使流行病预测复杂化.
研究的目的:
- 模拟定量耐药性对病原体进化的演示遗传影响.
- 调查景观结构和抵抗效率如何影响流行病结果.
主要方法:
- 开发了一个演示基因模型,将病原体的人口统计,遗传学和宿主-病原体相互作用联系起来.
- 模拟的病原体进化在对比的多年生宿主景观与不同的耐药性水平.
- 将完整模型模拟与简化版本进行比较,以评估模型的关键组件.
主要成果:
- 几乎完全的耐药性 (>99.99%) 有效地减少了流行病,并导致了病原体的专业化.
- 部分耐药性诱导了不适应性,有时与敏感种群相比,增加了宿主死亡率.
- 模型的复杂性,包括空间结构和病原体负载,显著影响预测.
结论:
- 高效率的定量耐药性是有效的,但可以推动病原体的专业化.
- 部分耐药性策略可能会产生意想不到的负面后果,包括增加疾病严重程度.
- 准确的建模需要结合病原体负载依赖的传播和景观空间性.
相关概念视频
Defenses Against Pathogens and Herbivores
26.9K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
26.9K
Antibiotic Selection
55.3K
Overview
55.3K
Development of Antibiotic Resistance
219
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
219
Gene Regulation in Microbial Communities: Quorum Sensing
97
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
97
Transduction
130
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
130
Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K


