在复发性复发性多发性硬化症患者中遵守治疗建议
Justyna Chojdak-Łukasiewicz1, Aleksandra Kołtuniuk2, Ewa Sawicka3
1Department of Neurology, Wroclaw Medical University, Wrocław, Poland.
Frontiers in immunology
|July 11, 2025
概括
多发性硬化症患者对疾病修饰疗法 (DMT) 的适度坚持. 疲劳显著影响治疗坚持,突出需要个性化护理策略.
科学领域:
- 神经学 神经学
- 临床药房 临床药房
- 患者报告的结果
背景情况:
- 坚持疾病修饰疗法 (DMT) 是管理多发性硬化症 (MS) 的关键.
- 了解患者对遵守的看法是改善疾病管理策略的关键.
研究的目的:
- 评估多发性硬化症患者的DMT坚持水平.
- 探索影响治疗坚持的患者相关因素.
主要方法:
- 一项对121名复发性复发性多发性硬化症患者 (90%为女性,平均年龄为34.0岁) 的调查.
- 使用的验证尺度:慢性疾病标准 (ACDS) 的遵守,患者健康问卷 (PHQ-9),修改疲劳影响量表 (MFIS),感知压力量表 (PSS-10) 和接受疾病量表 (AIS).
主要成果:
- 观察到对DMT的适度坚持 (平均ACDS得分为24.0 ± 3.8).
- 70%的患者报告的疲劳与较低的坚持有显著的相关性 (ACDS:R=-0.260,p=0.004).
- 疾病接受 (AIS) 与疲劳,抑郁 (PHQ-9) 和压力 (PSS-10) 有关,但与坚持 (ACDS) 没有直接关联.
结论:
- 多发性硬化患者对DMT的坚持是中度的,并且受到疲劳的显著影响.
- 评估坚持和心理社会因素对于制定个性化和有效的MS治疗计划至关重要.
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