肠道微生物群和甲状腺功能的新提议的饮食指数之间的关联:NHANES 2007-2012年
Ke Peng1, Hanjie Guo1, Zhiqiang Zhang1
1Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
Frontiers in nutrition
|July 11, 2025
概括
肠道微生物群 (DI-GM) 饮食指数的较高分数与较低的甲状腺激素水平相关,包括自由三甲状腺素 (FT3),自由甲状腺素 (FT4) 和总甲状腺素 (TT4). 年龄和吸烟情况显著影响了这些饮食-甲状腺关系.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 饮食-肠-甲状腺轴是一个不断增长的研究领域.
- 肠道微生物群的饮食指数 (DI-GM) 衡量与肠道微生物群多样性相关的饮食质量.
- DI-GM与甲状腺功能之间的关联仍未得到研究.
研究的目的:
- 研究肠道微生物群 (DI-GM) 的饮食指数与甲状腺功能之间的关系.
- 探索年龄和吸烟等因素如何改变这种关系.
主要方法:
- 从NHANES数据对6,126名参与者 (≥20年) 的横截面研究.
- 使用线性回归,平滑曲线拟合和子组分析.
- 研究了DI-GM得分与甲状腺激素水平 (FT3,FT4,TT4) 之间的关联.
主要成果:
- 更高的DI-GM得分与较低的FT3,FT4和TT4水平有显著的关联.
- 证实了DI-GM与FT3,FT4和TT4之间的线性关系.
- 年龄小于40岁的FT4下降更明显,DI-GM更高.
- 吸烟状态改变了这些关联,对从未吸烟者,以前吸烟者和现在吸烟者的FT3和TT4水平产生了明显的影响.
结论:
- 更高的DI-GM得分与关键甲状腺激素水平的降低有关.
- 年龄和吸烟状态是DI-GM和甲状腺功能关联的显著调节者.
- 需要进一步的研究来阐明饮食-肠-甲状腺轴背后的机制.
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