在精神分裂症的口语流利任务期间,特定于听觉口语幻觉的前时大脑活动的变化:一项fNIRS研究
Jiaxin Zhang1,2,3,4,5, Ju Tian5, Jiuju Wang5
1Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beihang University, Beijing, China.
Frontiers in neurology
|July 11, 2025
概括
精神分裂症和听觉语言幻觉 (AVH) 患者表现出不同的大脑活动模式. 功能近红外光谱学 (fNIRS) 发现AVH患者左侧STC激活减少,右侧vlPFC反应减缓,表明特定的神经差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症的听觉语言幻觉 (AVH) 会导致显著的功能障碍和社会负担.
- 虽然神经成像已经探索了AVH,但潜在的病理机制仍然不清楚.
- 功能近红外谱学 (fNIRS) 提供了一种便携式方法,用于研究与AVH相关的任务期间的大脑激活.
研究的目的:
- 通过使用fNIRS. 调查具有AVH (SZ-AVHs) 和没有AVH (SZ-nAVHs) 的精神分裂症患者之间的脑血液动力学功能差异.
- 为了确定与精神分裂症中AVH相关的神经异常.
- 在口头流利任务中检查大脑激活模式.
主要方法:
- 一个52通道的fNIRS系统监测了178个SZ-AVH和172个SZ-nAVH在口头流利性任务 (VFT) 期间的血液动力学变化.
- 记录了临床病史和症状严重程度.
- 尼尔斯帕克软件分析了fNIRS数据的脑功能固有值,包括积分 (激活度) 和心状 (响应速度) 值.
主要成果:
- 与SZ-nAVH相比,SZ-AVH在左上皮质 (STC) 中表现出明显更高的积分值.
- 与SZ-nAVH相比,SZ-AVH在右腹侧前额皮层 (vlPFC) 中的中心点值显著更高.
- 这些结果表明,特定区域的大脑激活和反应速度发生了变化.
结论:
- 患有AVH的精神分裂症患者在左侧STC表现出减少的激活.
- 与没有AVH患者相比,AVH患者在右侧vLPFC中反应速度也较慢.
- 这些发现突出了精神分裂症中AVH的特定神经相关性,有助于理解其病理生理学.
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