多发性硬化症患者手术的影响:全国范围的队列研究
Emma Larsson1,2, Ellen Iacobaeus3,4, Erik von Oelreich1,2
1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Frontiers in neurology
|July 11, 2025
概括
对于多发性硬化症 (MS) 患者来说,手术似乎是安全的,没有观察到增加的死亡风险. 虽然MS患者在手术后的诊断更多,但他们的疾病负担在几个月内恢复到基线,这表明谨慎管理是关键.
科学领域:
- 神经学 神经学
- 外科手术的结果
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经炎症性疾病.
- 手术可以引发全身炎症,可能会加剧MS.
- 手术对MS发病率和死亡率的影响尚不清楚.
研究的目的:
- 为了评估MS患者的外科病率.
- 为了比较MS患者和非MS患者手术后的疾病负担和死亡率.
主要方法:
- 一个瑞典队列研究超过150万次手术 (2019-2023).
- 包括3022名多发性硬化症患者和匹配的对照.
- 根据ICD代码评估的疾病负担,手术前后.
主要成果:
- 多发性硬化症患者手术前后诊断的平均数量较高.
- 诊断峰值发生在一个月内,在3-4个月后恢复到基线.
- 在MS和非MS患者之间30天或365天死亡率没有显著差异.
结论:
- 对于MS患者来说,手术通常是安全的.
- 医生不应该阻止必要的外科手术.
- 量身定制的术前和术后护理对于MS患者的最佳结果至关重要.
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