运动延迟衰老:来自端粒和端粒酶的证据 - - 一项随机对照试验的系统审查和元分析
Liang Sun1, Tingran Zhang1, Lanfang Luo2
1School of Physical Education, Southwest University, Chongqing, China.
Frontiers in physiology
|July 11, 2025
概括
运动干预有助于维持端粒长度 (TL) 和提高端粒酶活性 (TA),可能减缓衰老. 有氧运动 (AE) 对TA有强烈的影响,但对高强度间歇训练 (HIIT) 和抵抗运动 (RE) 需要更多的研究.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 衰老的研究研究.
背景情况:
- 端粒长度 (TL) 和端粒酶活性 (TA) 是细胞衰老的关键生物标志物.
- 了解运动如何影响这些标志物对于开发抗衰老策略至关重要.
- 目前关于炼对TL和TA的影响的证据需要进行系统评估.
研究的目的:
- 系统地评估运动干预对端粒长度 (TL) 和端粒酶活性 (TA) 的调节效应.
- 为制定基于端粒保护的精确运动处方提供证据.
- 综合随机对照试验 (RCT) 关于运动和端粒动态的研究结果.
主要方法:
- 进行全面的数据库搜索 (PubMed,科学网,Embase等) 对于RCT来说,直到2025年2月.
- 使用Cochrane风险评估工具进行包含的研究的质量评估.
- 使用Review Manager 5.3和Stata 18.0.0进行了元分析,异质性测试,子组分析和元回归.
主要成果:
- 运动干预显著维持了TL (SMD = 0.59) 和增强了TA (SMD = 0.35).
- 有氧运动 (AE) 持续增加了TA,而抵抗运动 (RE) 显示了无意义的趋势.
- 显著效果需要长达≥16周的炼时间;注意到高异质性.
结论:
- 运动,特别是AE,在维持TL和增强TA方面发挥着至关重要的作用,可能延缓衰老.
- 由于数据有限,高强度间歇训练 (HIIT) 和抵抗运动 (RE) 需要进一步调查.
- 未来的研究应该标准化测量方法,并探索饮食和遗传学等混因素.
更多相关视频
10:14Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol TRAP Assay
Published on: September 2, 2014
14.8K
08:34Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
10.4K
相关概念视频
Telomeres and Telomerase
5.4K
5.4K
Aging
191
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
191
The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
Replicative Cell Senescence
3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K
Replication in Eukaryotes
14.7K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
14.7K
Mitochondria
15.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.1K
