在间歇性缺氧下,芯片上的肌肉骨器官揭示了肌肉骨沟通
Xianqin Tong1,2, Minchao Liu3, Jiao Li1,2
1Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201100, China.
National science review
|July 11, 2025
概括
间歇性缺氧通过影响肌肉,损害骨健康. 一个新的器官芯片模型显示,肌肉中的Sirt3蛋白调节骨代谢,为新疗法提供了点.
科学领域:
- 生物医学工程 生物医学工程
- 生理学 生理学 生理学
- 再生医学是一种再生医学.
背景情况:
- 肌肉和骨具有密切的生化联系.
- 间歇性缺氧 (IH) 对肌肉与骨相互作用的影响由于缺乏适当的模型,因此尚不清楚.
研究的目的:
- 开发一种新的肌肉骨器官器官芯片 (MSK OoC) 平台,用于研究肌肉骨沟通.
- 研究IH对肌肉和骨的影响,并确定治疗点.
主要方法:
- 开发一种新的MSK OoC,集成肌肉有机体 (MO) 和骨有机体.
- 利用MSK OoC研究IH诱导的肌肉病理及其对骨的影响.
- 研究 mitochondrial 蛋白 Sirt3 和 myokine Cxcl5 在肌肉骨交叉声调中的作用.
- 使用向线粒体的纳米载体来输送白醇.
主要成果:
- 由IH诱导的肌肉病理抑制了骨形成 (骨质生成),并促进了骨再吸收 (骨质细胞生成).
- 肌肉中的线粒体Sirt3被确定为骨代谢的关键调节者,通过肌Cxcl5.5起作用.
- 在MOs中使用线粒体向序列的Sirt3过度表达逆转了骨质恶化.
- 在MSK OoC模型中,通过Janus二氧化纳米载体输送的白醇有效地挽救了肌肉骨功能障碍.
结论:
- MSK OoC平台是研究肌肉和骨之间的器官间通信的宝贵工具.
- 肌肉中的线粒体Sirt3在IH下是骨健康的关键调解者.
- 以线粒体为向的纳米医学对治疗肌肉骨病理具有前景.
相关概念视频
Skeletal Muscle Anatomy
89.7K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
89.7K
Bone Remodeling
38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
Overview of Skeletal Muscle
12.5K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
12.5K
Hormones and Bone Tissue
3.0K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.0K
Spongy Bone
5.4K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
5.4K
Hypoxia
1.2K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.2K


