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长非编码RNA在食道状细胞癌中的功能和机制 (综述)
Yuning Lin1, Zhenyi Lv1, Hongyan Xie1
1Medical Laboratory, Xiamen Humanity Hospital Fujian Medical University, Xiamen, Fujian 361009, P.R. China.
Oncology letters
|July 11, 2025
概括
长非编码RNAs (lncRNAs) 是食道状细胞癌 (ESCC) 的关键调节者. 了解lncRNA机制为这种致命的消化系统癌症提供了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 食道癌 (EC) 是一种流行且致命的消化系统恶性瘤.
- 它的发病包括复杂的多基因异常和表观遗传调节.
- 长非编码RNAs (lncRNAs) 是食道状细胞癌 (ESCC) 的关键调节元素.
研究的目的:
- 审查 lncRNAs 在 ESCC 病理生理学中的调节作用.
- 突出它们在食道癌发生过程中的潜在临床应用.
- 强调特定的监管轴和机制路径.
主要方法:
- 文献综述总结了ESCC中的lncRNA功能.
- 分析 lncRNA 机制,包括表观遗传修饰和竞争的内源性 RNA 网络.
- 讨论 lncRNA参与关键的生物过程,如增殖,入侵和转移.
主要成果:
- lncRNAs通过多种机制调节基因表达.
- 它们调节ESCC中的关键过程,包括瘤细胞的增殖,入侵,转移,亡,耐药性,辐射抵抗,干细胞特性和上皮细胞-介质细胞过渡.
- 特定的调节轴和机械途径在食道致癌过程中受到影响.
结论:
- lncRNAs在ESCC的发展和进展中起着重要的作用.
- 需要进一步探索lncRNA分子机制.
- lncRNAs的翻译应用可能会改善预后结果,并在ESCC中确定精密瘤学的新疗法标.
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